The Hill lab uses a variety of techniques, particularly X-ray crystallography, to study how multi-protein complexes assemble, function, and move.  Biological systems currently under study include HIV assembly and budding, proteasome activation, heme biosynthesis, and nucleosome remodeling/reorganization.  Together with Sundquist’s group, Hill’s group determined crystal structures of viral proteins that function in assembly and structure of the virus particle, and cellular proteins that function in viral budding.