The Protein NMR Spectroscopy Core focuses on using NMR spectroscopy to determine the three dimensional structures of proteins and protein complexes relevant to HIV-1/Host biology.  Our on site Laboratory for Biomolecular NMR Spectroscopy is housed in room 50 of the Biomedical Polymers Research Building, located adjacent to the Biochemistry Dept at the University of Utah.  We also have very substantial capacity for adding new NMR spectrometers in the Emma Eccles Jones Medical Research Building, EEJMRB, (Biochemistry Dept.) and within the David M. Grant NMR Center (Chemistry Dept.). The David M. Grant NMR Center is home to a new state of the art NMR facility (15,000 sq. ft. of laboratory space) on the basic science campus of the University of Utah (about ½ mile from the Biomolecular NMR Center), with space for multiple high-field NMR spectrometers.

The Laboratory for Biomolecular NMR Spectroscopy currently houses two high field NMR spectrometers: a Varian Inova 600 and Inova 500. We also have dedicated time on off site 800 and 900 MHz NMR spectrometers.  The Varian Inova 800 is housed in Boulder, Colorado. This spectrometer was purchased as part of a shared instrumentation grant to Arthur Pardi (UC Boulder) that included the University of Utah, University of Colorado, Boulder, and the University of Colorado Health Science Center (UCHSC), Denver. The Varian Inova 900 is housed in Denver, Colorado. This Rocky Mountain 900 MHz NMR Facility was established through a grant from NIH General Medical Sciences and is charged with serving the high field NMR requirements of publicly funded research institutions in Rocky Mountain/West Central states. The consortium consists of 17 research groups from 9 institutions in 6 states including the University of Utah (~10% of the instrument time).