PEOPLE
Wes Sundquist, Director
Pamela Bjorkman Debbie Eckert Nels Elde Adam Frost Chris Hill Tom Hope Janet Iwasa Grant Jensen Michael Kay Anthony Kossiakoff Neil King Walther Mothes Elisabetta Viani Puglisi Barbie Ganser-Pornillos Greg Voth Mark Yeager Scientific Advisory Board Collaborative Development Program Awardees |
Tom Hope
Hope’s laboratory studies the cell biology of HIV using advanced microscopy. These techniques include photobleaching and photoactivation to define the localization and mobility of HIV Gag and HIV receptors in living cells. Together with collaborators, Hope developed techniques for labeling HIV virions with the green fluorescent protein, thereby allowing individual virions to be followed by fluorescence microscopy in living cells. Using this technology, Hope’s group showed that HIV utilizes the microtubule network to traffic to the nucleus, that HIV infection is stimulated by dendritic cells through the formation of an infectious synapse, and that the antiviral action of the HIV restriction factor TRIM5a is mediated in multiple phases.
Tom Hope, PhD
Professor of Cell and Molecular Biology Northwestern University Medical School 303 E. Chicago Avenue, Ward 8-140 Cell and Molecular Biology Department Chicago, Illinois 60611 Phone: (312) 503-1360 Fax: (312) 503-7912 Email: thope@northwestern.edu Web page: http://labs.feinberg.northwestern.edu/hope/  |